The ABC of EF-G
نویسندگان
چکیده
منابع مشابه
Ribosomal translocation: EF-G turns the crank
Recent results from cryo-electron microscopy have shown that substantial structural rearrangements in both elongation factor EF-G and the ribosome occur during tRNA translocation. The observed sites of interaction between EF-G and the ribosome are consistent with molecular mimicry models for EF-G function.
متن کاملA fast dynamic mode of the EF-G-bound ribosome.
A key intermediate in translocation is an 'unlocked state' of the pre-translocation ribosome in which the P-site tRNA adopts the P/E hybrid state, the L1 stalk domain closes and ribosomal subunits adopt a ratcheted configuration. Here, through two- and three-colour smFRET imaging from multiple structural perspectives, EF-G is shown to accelerate structural and kinetic pathways in the ribosome, ...
متن کاملCleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
Ribotoxins are potent inhibitors of protein biosynthesis and inactivate ribosomes from a variety of organisms. The ribotoxin alpha-sarcin cleaves the large 23S ribosomal RNA (rRNA) at the universally conserved sarcin-ricin loop (SRL) leading to complete inactivation of the ribosome and cellular death. The SRL interacts with translation factors that hydrolyze GTP, and it is important for their b...
متن کاملAccurate level energies in the EF 1 ' Y g , GK 1 ' Y g , H 1 ' Y g , B
By combining results from a Doppler-free two-photon laser excitation study on several lines in the EF'g X 'g (0,0) band of H2 with results from a Fourier-transform spectroscopic study on a low-pressure discharge in hydrogen, absolute level energies, with respect to the X g , v1⁄4 0, N1⁄4 0 ground level, were determined for 547 rovibronically excited states in H2. While for some of the levels in...
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cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
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ژورنال
عنوان ژورنال: Structure
سال: 1994
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(94)00078-6